Carbamazepine

Overview

Carbamazepine is a dibenzapine derivative with antiepileptic and anticonvulsant properties. Carbamazepine is closely related to Imipramine and other antidepressants. Carbamazepine is a tricyclic compound effective in the treatment of bipolar effective disoredrs. It was initally marketed for the treatment of trigeminal neuralgia but has proved useful for epilepsy as well. Carbamazepine is now used as a drug of choice for simple and complex partial seizures and for tonic clonic seizures. It is also used for the management of certain types of nerve pain.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

Oral absorption of Carbamazepine is found to be 84% ±12. Volume of distribution is found to be 0.8-2 l/Kg and plasma protien binding is 54-80%. Renal Excretion accounts for 1% (unchanged) and plasma half life is 30-40 hr.

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Contraindications

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Drug Interactions

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Side Effects

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Dosage

Carbamazepine's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

100 to 200 mg150 (150)12 hourlyPOAs initial dose.
800 to 1200 mg1000 (1000)As recommended.POIn div.doses. Maximum dose: for 12-15 years; 1000 mg/day. for > 15 years; 1.6-2.4 g/day.

Paedriatic Dosage (20kg)

5 to 10 mg/kg7.5 (7.5)12 hourlyOral-

Neonatal Dosage (3kg)

5 to 10 mg/kg7.5 (7.5)12 hourlyOral-

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Carbamazepine

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