Ceftriaxone (Na)

Overview

Ceftriaxone is a third generation, semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Ceftriaxone is a broad spectrum, ß lactmase resistant antibiotic effective against a wide range of gram positive and gram negative bacterias. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Ceftriaxone (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

Categories

• 6 Anti-infective drugs
  • 6.2 Antibiotics, systemic
    • 6.2.1 Beta-lactam drugs
      • 6.2.1.3 Cephalosporins

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Ceftriaxone (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1 g	1 (1)	24 hourly		0.5-2 pre-operatively for prophylaxis against infection in surgery.
0.25 to 0 g	0.12 (0.125)	As recommended.	IM	For uncompleted Gonnorrhoea
1 to 2 g	1.5 (1.5)	24 hourly	IV,IM	Once daily or in two divided doses. Max. dose: 4 g/day. Given by IV infusion over atleast 30 minutes.
Paedriatic Dosage (20kg)
0 to 125 mg	62 (62.5)	As recommended.		For prevention of secondary cases of mennigococcal meningitis
20 to 50 mg/kg	35 (35)	24 hourly	Intra Venous	For serve infections up to 80mg/kg daily should be given
Neonatal Dosage (3kg)
50 mg/kg	50 (50)	24 hourly	Intra Venous	IV doses should be given over 60 min doses above 50mg/kg should be given by IV infusion only

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Ceftriaxone (Na)

Manufacturers of Ceftriaxone (Na) in Pakistan

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