Cefuroxime

Overview

Cefuroxime is a second generation, semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cefuroxime is a broad spectrum ß lactamase resistant antibiotic effective against a wide range of gram positive and gram negative bacteria. Cefuroxime (Na) is less effective against gram positive bacterias than first generation drugs. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefuroxime (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Cefuroxime axetil is an oral second generation cephalosporin antibiotic and used in the treatment of uncomplicated urinary tract infection, respiratory infections, bone and joints infection, gonorrhoea, otitis media, sinusitis and some skin infections.

Categories

• 6 Anti-infective drugs
  • 6.2 Antibiotics, systemic
    • 6.2.1 Beta-lactam drugs
      • 6.2.1.3 Cephalosporins

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Cefuroxime's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
750 mg	750 (750)	12 hourly	iv	for pneumonia and with acute exacerbations of chronic bronchitis 1.5 mg may be given every 8 hour in more severe conditions.
250 to 500 mg	380 (375)	12 hourly	PO	Should be taken after food for optimum absorption. The usual course is seven days. For respiratory tract infection.
Paedriatic Dosage (20kg)
250 to 0 mg	120 (125)	12 hourly		otitus media over 2 years of age.
15 to 0 mg/kg	7.5 (7.5)	12 hourly		maximum of 500mg daily
Neonatal Dosage (3kg)
10 mg/kg	10 (10)	12 hourly		maximum of 250mg daily. More than 3 months of age.
125 mg	120 (125)	12 hourly		maximum of 500mg daily. More than 3 months of age.

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Cefuroxime

Manufacturers of Cefuroxime in Pakistan

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