Cephradine

Overview

Cephradine is a first generation, semisynthetic analogue of natural cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cephradine is effective against gram positive and gram negative bacterias. Administered orally or by intramuscularly or by intravenous injection. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cephradine is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

Categories

• 6 Anti-infective drugs
  • 6.2 Antibiotics, systemic
    • 6.2.1 Beta-lactam drugs
      • 6.2.1.3 Cephalosporins

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Cephradine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2 to 4 g	3 (3)	As recommended.	IV /IM	Over 3-5 min (in 4 divided doses),(up to 8g daily inverse infections.
1 to 2 g	1.5 (1.5)	6 hourly	P/O	2-4 divided doses (up to 4g)
1 to 2 g	1.5 (1.5)	As recommended.	PO	For surgical prophylaxis
Paedriatic Dosage (20kg)
50 to 100 mg/kg	75 (75)	As recommended.	IV/IM	For Paeds of All Ages . given in 4 divided doses .This dose is for severe infections.(to maximum of
75 to 100 mg/kg	88 (87.5)	24 hourly	P/O	Otilis media
25 to 50 mg/kg	38 (37.5)	As recommended.	PO	Given in 2-4 divided doses
Neonatal Dosage (3kg)
6.3 to 12.5 mg/kg	9.4 (9.4)	6 hourly	oral

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Cephradine

Manufacturers of Cephradine in Pakistan

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