Chlorpromazine (HCl)

Overview

Chlorpromazine (HCl) is the hydrochloride salt of chlorpromazine which is a phenothiazine derivative. It is used as an antiemetic, antipsychotic and tranquilizer. Chlorpromazine (HCl) is administered by rectal suppositories.

Categories

• 24 Psychotherapeutic drugs
  • 24.1 Drugs used in psychotic disorders

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Chlorpromazine (HCl) is contraindicated in conditions like Epilepsy, Myasthenia gravis, Narrow-angle glaucoma, Parkinson's disease, Depressed level of conciousness.

Drug Interactions

Side Effects

Dosage

Chlorpromazine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
25 to 50 mg	38 (37.5)	As recommended.	IV,IM	Repeated every 4-6hours. To maximum of 400 mg.
10 to 25 mg	18 (17.5)	8 hourly	PO
Paedriatic Dosage (20kg)
0.5 mg/kg	0.5 (0.5)	6 hourly	Intra Muscular	Should not be used under 6 months of age.
0.5 mg/kg	0.5 (0.5)	6 hourly	Intra Venous	Should not be used under 6 months of age.
0.5 mg/kg	0.5 (0.5)	6 hourly	Oral	Should not be used under 6 months of age.
Neonatal Dosage (3kg)
0.5 mg/kg	0.5 (0.5)	4 hourly	Intramuscular
0.5 mg/kg	0.5 (0.5)	4 hourly	Intravenous
0.5 mg/kg	0.5 (0.5)	4 hourly	oral

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

• Urinary Ferric Chloride test for phenylketonuria may be falsely positive.
• Altered urinary excretion of vanillylmandelic acid, 17-ketosteroids and 17-OH corticosteroids.
• Immunological Tests for Pregnancy may be falsely positive.

Brands / Trade Names of Chlorpromazine (HCl)

Manufacturers of Chlorpromazine (HCl) in Pakistan

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