Chlorpromazine (HCl)

Overview

Chlorpromazine (HCl) is the hydrochloride salt of chlorpromazine which is a phenothiazine derivative. It is used as an antiemetic, antipsychotic and tranquilizer. Chlorpromazine (HCl) is administered by rectal suppositories.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

Chlorpromazine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Benzhexol (HCl)

Interaction of Benzhexol (HCl) with Chlorpromazine (HCl)

Bethanidine (Sulphate)

Interaction of Bethanidine (Sulphate) with Chlorpromazine (HCl)

Bovine Insulin

Interaction of Bovine Insulin with Chlorpromazine (HCl)

Metoclopramide (HCl)

Interaction of Metoclopramide (HCl) with Chlorpromazine (HCl)

Clonidine (HCl)

Interaction of Clonidine (HCl) with Chlorpromazine (HCl)

Alcohol

Interaction of Alcohol with Chlorpromazine (HCl)

Guanethidine

Interaction of Guanethidine with Chlorpromazine (HCl)

Lithium

Interaction of Lithium with Chlorpromazine (HCl)

Methyldopa

Interaction of Methyldopa with Chlorpromazine (HCl)

Clonidine (HCl)

Interaction of Clonidine (HCl) with Chlorpromazine (HCl)

Cyclophosphamide

Interaction of Cyclophosphamide with Chlorpromazine (HCl)

Debrisoquine (Sulphate)

Interaction of Debrisoquine (Sulphate) with Chlorpromazine (HCl)

Dexamphetamine (Sulphate)

Interaction of Dexamphetamine (Sulphate) with Chlorpromazine (HCl)

Disulfiram

Interaction of Disulfiram with Chlorpromazine (HCl)

Glibornuride

Interaction of Glibornuride with Chlorpromazine (HCl)

Gliquidone

Interaction of Gliquidone with Chlorpromazine (HCl)

Guanethidine

Interaction of Guanethidine with Chlorpromazine (HCl)

Human Insulin

Interaction of Human Insulin with Chlorpromazine (HCl)

Imipramine (HCl)

Interaction of Imipramine (HCl) with Chlorpromazine (HCl)

Methyldopa

Interaction of Methyldopa with Chlorpromazine (HCl)

Methylphenidate (HCl)

Interaction of Methylphenidate (HCl) with Chlorpromazine (HCl)

Nalidixic Acid

Interaction of Nalidixic Acid with Chlorpromazine (HCl)

Pethidine (HCl)

Interaction of Pethidine (HCl) with Chlorpromazine (HCl)

Phenytoin (Na)

Interaction of Phenytoin (Na) with Chlorpromazine (HCl)

Piperazine

Interaction of Piperazine with Chlorpromazine (HCl)

Porcine Insulin

Interaction of Porcine Insulin with Chlorpromazine (HCl)

Propranolol (HCl)

Interaction of Propranolol (HCl) with Chlorpromazine (HCl)

Epirubicin

Interaction of Epirubicin with Chlorpromazine (HCl)

Protirelin

Interaction of Protirelin with Chlorpromazine (HCl)

Terazosin

Interaction of Terazosin with Chlorpromazine (HCl)

Fosphenytoin

Interaction of Fosphenytoin with Chlorpromazine (HCl)

Thalidomide

Interaction of Thalidomide with Chlorpromazine (HCl)

Insulin Lispro

Interaction of Insulin Lispro with Chlorpromazine (HCl)

Benztropine (Mesylate)

Interaction of Benztropine (Mesylate) with Chlorpromazine (HCl)

Details: Antimuscarinics (e.g Benztropine) possibly reduce plasma concentration of Chlorpromazine.
Diazoxide

Interaction of Diazoxide with Chlorpromazine (HCl)

Details: Enhanced hypotensive effect when Diazoxide Chlorpromazine.
Halothane

Interaction of Halothane with Chlorpromazine (HCl)

Hydroxocobalamin

Interaction of Hydroxocobalamin with Chlorpromazine (HCl)

Riboflavin (Vitamin B2)

Interaction of Riboflavin (Vitamin B2) with Chlorpromazine (HCl)

Details: Chlorpromazine may lower riboflavin levels.
Nitroglycerin

Interaction of Nitroglycerin with Chlorpromazine (HCl)

Details: simultaneous use of nitroglycerin and phenothizines may cause orthostatic hypotension
Belladona

Interaction of Belladona with Chlorpromazine (HCl)

Details: Antimuscarinics reduce plasma concentration of phenothiazine (e.g Chlorpromazine), but risk of antimuscarinic side-effects increased.
Metacycline (HCl)

Interaction of Metacycline (HCl) with Chlorpromazine (HCl)

Details: Chlorpromazine (HCl), fluphenazine and other phenothizines causes extrapyramidal reactions.
Pramipexole

Interaction of Pramipexole with Chlorpromazine (HCl)

Details: Chlorpromazine (HCl) may decrease the efficiency of pramipexole due to dopamine antagonism.
Potassium Clorazepate

Interaction of Potassium Clorazepate with Chlorpromazine (HCl)

Details: Effects of Potassium Clorazepate may be potentiated by Chlorpromazine (HCl).
Vortioxetine

Interaction of Vortioxetine with Chlorpromazine (HCl)

Details: increases the level of vortioxetine
Management: monitor closely, use alternative

Minor

Cimetidine (HCl)

Interaction of Cimetidine (HCl) with Chlorpromazine (HCl)

Details: Cimetidine reduces the therapeutic effects of chlorpromazine.
Management: Reduce the dose of chlorpromazine if necessary

Moderate

Metformin (HCl)

Interaction of Metformin (HCl) with Chlorpromazine (HCl)

Details: Chlorpromazine decreases the hypoglycemic effect of metformin by interfering with blood glucose control.
Management: Closely monitor the blood glucose level. Adjust the dose of metformin accordingly.
Perindopril

Interaction of Perindopril with Chlorpromazine (HCl)

Details: Theoretical potential for CHLORPROMAZINE increasing the HYPOTENSIVE effect of Perindopril Erbumine.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Chlorpromazine (HCl)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
25 to 50 mg38 (37.5)As recommended.IV,IMRepeated every 4-6hours. To maximum of 400 mg.
10 to 25 mg18 (17.5)8 hourlyPO

Paedriatic Dosage (20kg)
0.5 mg/kg0.5 (0.5)6 hourlyIntra MuscularShould not be used under 6 months of age.
0.5 mg/kg0.5 (0.5)6 hourlyIntra VenousShould not be used under 6 months of age.
0.5 mg/kg0.5 (0.5)6 hourlyOralShould not be used under 6 months of age.

Neonatal Dosage (3kg)
0.5 mg/kg0.5 (0.5)4 hourlyIntramuscular
0.5 mg/kg0.5 (0.5)4 hourlyIntravenous
0.5 mg/kg0.5 (0.5)4 hourlyoral

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Chlorpromazine (HCl)

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Manufacturers of Chlorpromazine (HCl) in Pakistan

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