Clonazepam

Overview

Clonazepam is a benzodiazipine. Benzdiazipines are the most widely used anxiolytic drugs. The benzodiazipines are more effective and safer. They have largely replaced barbiturates and meprobamate in the treatement of anxiety.

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

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Side Effects

The severe or irreversible adverse effects of Clonazepam, which give rise to further complications include Thrombocytopenia, Abnormal LFT, Blood dyscrasias.

Clonazepam produces potentially life-threatening effects which include Apnea, Hypotension. which are responsible for the discontinuation of Clonazepam therapy.

The signs and symptoms that are produced after the acute overdosage of Clonazepam include Somnolence, Ataxia, Drowsiness, Hypotonia.

The symptomatic adverse reactions produced by Clonazepam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Fatigue, Anorexia, Tachycardia, Sleep disturbancesX, Rashes, VertigoX, Impotence, Loss of libido, SomnolenceX, Macular hypotonia, Coordination disturbances, Abnormal thirst, Skin pigmentation, Facial edema, Increased intracranial pressure, Vision disturbances.

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Dosage

Clonazepam's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

0.125 to 1 mg0.56 (0.5625)24 hourlyPOInitial
1 to 4 mg2.5 (2.5)24 hourlyPOMaintenance

Paedriatic Dosage (20kg)

25 ug/kg25 (25)24 hourlyOralInitially at night
50 to 150 ug/kg100 (100)12 hourlyOralMaintenance

Neonatal Dosage (3kg)

31.25 ug/kg31 (31.25)24 hourlyoralload for once
62.5 ug/kg62 (62.5)12 hourlyoralMaintenance, As required

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Clonazepam

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