Glyceryl Trinitrate

Overview

Glyceryl Trinitrate is a vasodialator (expands the blood vessels) Glyceryl Trinitrate is used for syptomatic treatment of angina to treat cardiac failure and during hypotensive or cardiac surgery to prevent myocardial infarction.

Categories

Primary Characterstics

Indications

Glyceryl Trinitrate is primarily indicated in conditions like Anal fissure, Angina pectoris, Cardiac failure, Cardiopulmonary oedema, Long-term treatment of healed reflux oesophagitis, Moderate to severe reflux oesophagitis, Myocardial infarction, Oesophageal spasm, Oesophageal spasm, Postoperative hypertension, Prinzmetal's angina, Prophylaxis of angina, Unstable angina.

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Pharmacokinetics

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Contraindications

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Drug Interactions

Glyceryl Trinitrate is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Imipramine (HCl)

Interaction of Imipramine (HCl) with Glyceryl Trinitrate

Alcohol

Interaction of Alcohol with Glyceryl Trinitrate

Atropine (Sulphate)

Interaction of Atropine (Sulphate) with Glyceryl Trinitrate

Heparin (Na) and Heparin (Cl)

Interaction of Heparin (Na) and Heparin (Cl) with Glyceryl Trinitrate

Rauwolfia Reserpine

Interaction of Rauwolfia Reserpine with Glyceryl Trinitrate

Reserpine

Interaction of Reserpine with Glyceryl Trinitrate

Quinagolide (HCl)

Interaction of Quinagolide (HCl) with Glyceryl Trinitrate

Alprostadil

Interaction of Alprostadil with Glyceryl Trinitrate

Details: Enhanced hypotensive effects when alprostadil given with Nitrates (e.g Glyceryl trinitrate).
Ergotamine (Tartrate)

Interaction of Ergotamine (Tartrate) with Glyceryl Trinitrate

Details: glyceryl trinitrate increase oral bioavailibilty and plasma concentration of dihydroergotamine in patients with orthostatic hypotension
Aspirin

Interaction of Aspirin with Glyceryl Trinitrate

Apomorphine

Interaction of Apomorphine with Glyceryl Trinitrate

Details: Sublingual apomorphine enhances hypotensive effecs of nitrates.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Glyceryl Trinitrate's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
10 to 200 mcg100 (105)As recommended.IV
300 to 600 ug450 (450)As recommended.Sublingualplaced under the tongue 3 doses of glyceryl trinitrate can be repeated every with in 15 minutes untill pain relieves.
400 ug400 (400)As recommended.Topical(Aerosol spray)Each are directed on to or under the tongue.

Paedriatic Dosage (20kg)
Not Recommended in this Age Group

Neonatal Dosage (3kg)
Not recommended in this age group

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Glyceryl Trinitrate

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