Hydralazine (HCl)

Overview

Hydralazine is antihypertensive agent. It acts as a vasodilator. It relaxes and expands blood vessels and lowers the blood pressure. It also function as antioxidant. It has been available for many years, though it was initially thought not to be particularly effective because tachyphylaxis to hypertensive effects developed rapidly. Now the benefits of combination therapy are recognized, and may be used more effectively particularly in severe hypertension.

Categories

• 12 Cardiovascular drugs
  • 12.3 Anti-hypertensives
  • 12.3.7 Direct vasodilators

Page headings

Primary Characterstics

Indications

Hydralazine (HCl) is primarily indicated in conditions like Benign gastric and duodenal ulcers, Heart failure, Hypertension, Hypertension with renal complications and hypertensive crisis (including during pregnancy), Hypertensive emergencies, Moderate to severe hypertension, Moderate to severe hypertension (adjunct), Primary pulmonary hypertension, Severe or recurrent duodenal and gastric ulcertion, and can also be given in adjunctive therapy as an alternative drug of choice in Heart failure (with long acting nitrate).

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Hydralazine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
100 to 300 mg	200 (200)	As recommended.	PO	Maintanace, as required.
25 mg	25 (25)	6 hourly	PO	Initially for Several Weeks
Paedriatic Dosage (20kg)
0.1 to 0 mg/kg	0.05 (0.05)	As recommended.	Intra Muscular	Initially for Once or repeated after 30 Minutes
0.25 to 0.5 mg/kg	0.38 (0.375)	6 hourly	Oral	Maintenance, As Required
0.1 to 0 mg/kg	0.05 (0.05)	As recommended.	Slow IV	Initially for Once or repeated after 30 Minutes
Neonatal Dosage (3kg)
0.2 mg/kg	0.2 (0.2)	As recommended.	Intra Muscular	Initially for Once or repeated after 30 Minutes
0.25 to 0.5 mg/kg	0.38 (0.375)	6 hourly	Oral	Maintenance, As Required
0.2 mg/kg	0.2 (0.2)	As recommended.	Slow IV	Initially for Once or repeated after 30 Minutes

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Hydralazine (HCl)

Manufacturers of Hydralazine (HCl) in Pakistan

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