Interferon Beta
Overview
Interferons are potent cytokines that possess antiviral, immunomodulating and antiproliferative actions. The interferones bind to specific cell-surface receptors that initiate a series of intracellular events, induction of certain enzymes, inhibition of cell-proliferation, and enhancement of immune activities. It (IFNB) is a type of interferon produced by fibroblasts and epithelial cells. The term "it" used here encompasses products that are further differentiated as either it-1a or it-1b. it-I a, a 166-amino acid recombinant glycoprotein, and it-I b, a 165-amino acid recombinant protein, used in the treatment of multiple sclerosisto reduce the frequency of clinical exacerbations.
Categories
- 8 Antineoplastics, immunomodulators and drugs used in palliative care
Primary Characterstics
Indications
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Pharmacokinetics
Volume of distribution is found to be 3 l/kg . Plasma half life is 10hr beta 1a.
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Contraindications
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Side Effects
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Dosage
Interferon Beta's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 0.25 mg | 0.25 (0.25) | As recommended. | SC | Should be injected every other day. Generally, patients should be started at 0.0625 mg (0.25 mL) subcutaneously every other day, and increased over a six week period to 0.25 mg (1.0 mL) every other day |
Paedriatic Dosage (20kg)
|
| No data regarding the Paedriatic dosage details of Interferon Beta is available. |
Neonatal Dosage (3kg)
|
| No data regarding the neonatal dosage details of Interferon Beta is available. |
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Interferon Beta
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Manufacturers of
Interferon Beta
in Pakistan
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