Loperamide (HCl)

Overview

Loperamide (HCl) is antidiarrheal agent. Loperamide (HCl) is chemically related to haloperidol, acting diractly on the intestinal wall o inhibit paristalsis. It acts mora rapidly and is longer acting than diphenoxylate and cogeine. Loperamide (HCl) is also effective to reduce the amount of discharge from ileostomies. Loperamide (HCl) is prepared by chemical synthesis. Loperamide (HCl) is administered orally.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

Loperamide (HCl) is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Cholestyramine

Interaction of Cholestyramine with Loperamide (HCl)

Colestipol (HCl)

Interaction of Colestipol (HCl) with Loperamide (HCl)

Desmopressin (Acetate)

Interaction of Desmopressin (Acetate) with Loperamide (HCl)

Details: Plasma concentration of oral Desmopressin increased by Loperamide.Loperamide increase fastrointestinal absorption of desmopressin.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Loperamide (HCl)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
4 to 16 mg10 (10)24 hourlyPOFollowed by 2mg/dose after each stool upto max dose of 16mg/day.

Paedriatic Dosage (20kg)
0.05 mg/kg0.05 (0.05)6 hourlyOral-

Neonatal Dosage (3kg)
No data regarding the neonatal dosage details of Loperamide (HCl) is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Loperamide (HCl)

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