Midazolam
Overview
Midazolam is a very short-acting parenteral benzodiazepine. Midazolam is used intramuscularly or intravenously for conscious sedation during minor surgical or diagnostic procedures, as an inducing agent, or as an adjunct to regional anesthesia. It was originally thought to be preferable to other benzodiazepines for conscious sedation because of its potency and its short duration of action, however, comparisons with diazepam, an agent with a much longer half-life, have not revealed a consistent advantage of it. It received FDA approval in December 1985. It can produce any level of CNS depression required including sedation, hypnosis, skeletal muscle relaxation, or anticonvulsant activity. The action of Midazolam is mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Midazolam is also used in the treatment of anxiety and seizures.
Categories
- 24 Psychotherapeutic drugs
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Midazolam's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 2 mg | 2 (2) | As recommended. | IV | Initial dose over 30 sec. followed after 2 min. by increments of 0.5 -1 mg, usual range 2.5-7.5mg |
Paedriatic Dosage (20kg)
|
| | | | Not recommended for this age group |
Neonatal Dosage (3kg)
|
| | | | Not recommended in this age group |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Midazolam
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