Ondansetron (HCl)

Overview

Ondansetron (HCl) is oral and parenteral antiemetic agent. Ondansetron (HCl) is the first selective serotonin blocking agent to be marketed. Ondansetron (HCl) is extremely safe and highly effective antiemetic that has greatly improved the ability to give chemotherapy. The quality of life of patients has been tremendously better with ondansetron than with older, traditional antiemetics. Despite its effectiveness, ondansetron is not recommended for the routine treatment of nausea due to its significant cost. Ondansetron was originally approved for the treatment of chemotherapy-induced nausea/vomiting by the FDA in January 1991 and tablets were approved for the treatment of post-operative nausea/vomiting in April 1995. It may have central and/or peripheral action, selectively blocks the serotonin 5-HT1 receptors. 5-HT 1receptors are found centrally in the chemoreceptor trigger zone and peripherally at vagal nerve terminals in the intestines.

Categories

• 17 Gastrointestinal drugs
  • 17.2 Antiemetics & antinauseants

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Ondansetron (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
8 mg	8 (8)	12 hourly	Oral	2 hour before treatment
24 mg	24 (24)	8 hourly	PO	Oral dose is recommended 30 min before start of sinle day chemothrophy.
16 mg	16 (16)	As recommended.	Rectally	1 to 2 hour before treatment
8 mg	8 (8)	4 hourly	Slow IV/IM	Max. Dose =32 mg. Give 30 Min. before emetogenic drugs.
Paedriatic Dosage (20kg)
5 mg/m2	5 (5)	As recommended.	IV Infusion	Initially for 15 Min (Rec. for 5-12 Yrs)
4 mg	4 (4)	2 hourly	Oral	Maintenance for 5 Days
Neonatal Dosage (3kg)
No data regarding the neonatal dosage details of Ondansetron (HCl) is available.

High Risk Groups

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Ondansetron (HCl)

Manufacturers of Ondansetron (HCl) in Pakistan

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