Pamidronate (Disodium Pentahydrate)
Overview
Chemically Pamidronate (Disodium Pentahydrate) is (3-amino-1-hydroxypropylidene) biphosphonic acid disodium salt pentahydrate. It reduces the blood calcium levels in tumour-induced hypercalcemia to has a slow onset of action so is not suitable for initial treatment of severe hypercalacaemia . It inhibits resorption, so is used to treat Paget's disease of bone. Pamidronate (Disodium Pentahydrate) is also used in the treatment of osteoporosis, to reduce bone pain associated with myeloma and breast cancer. Pamidronate (Disodium Pentahydrate) is prepaed by chemical synthesis and available in any combination preparations. Pamidronate (Disodium Pentahydrate) is administered intravenously.
Categories
- 18 Hormones and other endocrine drugs and contraceptives
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Pamidronate (Disodium Pentahydrate)'s dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 30 to 90 mg | 60 (60) | As recommended. | IV | Once or As Required |
| 200 mg | 200 (200) | 24 hourly | PO | |
Paedriatic Dosage (20kg)
|
| No data regarding the Paedriatic dosage details of Pamidronate (Disodium Pentahydrate) is available. |
Neonatal Dosage (3kg)
|
| No data regarding the neonatal dosage details of Pamidronate (Disodium Pentahydrate) is available. |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Pamidronate (Disodium Pentahydrate)
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Manufacturers of
Pamidronate (Disodium Pentahydrate)
in Pakistan
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