Severity N/A
Clonidine (HCl) Interaction of Clonidine (HCl) with Tamsulosin Hydrochloride
Details: Concomitant use of these two drugs can potentially cause symptomatic hypotension.
Interaction of Warfarin (Na) with Tamsulosin Hydrochloride
Details: Concomitant use of these two drugs can potentially cause symptomatic hypotension.
Interaction of Ketoconazole with Tamsulosin Hydrochloride
Details: Tamsulosin is extensively metabolized, mainly by CYP3A4 and CYP2D6. Therefore should not be used in combination with strong inhibitors of CYP3A4 e.g Ketoconazole.
Interaction of Cimetidine (HCl) with Tamsulosin Hydrochloride
Details: Concurrent use causes significant changes in both tamsulosin hydrochloride clearance (26% decrease) and exposure (44% increase in AUC).
Interaction of Erythromycin with Tamsulosin Hydrochloride
Details: Tamsulosin Hydrochloride should be used with caution in combination with Erythromycin.
Interaction of Paroxetine with Tamsulosin Hydrochloride
Details: Tamsulosin Hydrochloride should be used with caution in combination with Paroxetine.
Interaction of Terbinafine (HCl) with Tamsulosin Hydrochloride
Details: Tamsulosin Hydrochloride should be used with caution in combination with Terbinafine (HCl).
Interaction of VORICONAZOLE with Tamsulosin Hydrochloride
Details: Voriconazole may increase the serum concentration of tamsulosin by decreasing its metabolism.
Management: Monitor for changes in the therapeutic and adverse effects