Thiamine HCl (Vitamin B1)

Overview

Thiamine HCl (Vitamin B1) is a heat labile, water soluble bicyclic compound. Thiamine HCl (Vitamin B1) is made up of a substituted pyramidine ring connected by a methylene bridge to the nitrogen of a substituted thiazole ring. Thiamine HCl (Vitamin B1) is involved in carbohydrate metabolism in the body. it's supplements are required to treat or prevent stomach, heart or nerve problems caused by inappropriate amount of thiamine. Thiamine deficiency can occur as a result of malnutrition or in conditions requiring increased need, such as pregnancy or illness. Thiamine HCl (Vitamin B1) is widely distributed in food, found in all plants and synthesized by some microrganisms, perticularly yeast. Cereals, nuts, peas, beans, liver, heart or kidney and fish are rich sources of thiamine.

Categories

• 27 Vitamins, minerals, tonics, and other susbstances

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Oral absorption of Thiamine HCl (Vitamin B1) is found to be 73% ±2. Plasma protien binding is 90-94%. and metabolism is reported hepatic. Plasma half life is 24 hr.

Contraindications

Drug Interactions

Side Effects

Dosage

Thiamine HCl (Vitamin B1)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
100 to 300 mg	200 (200)	24 hourly	PO,IM	IV doses should be administered slowly atleast over 20 min to reduce Idiosyncratic reactions
Paedriatic Dosage (20kg)
1 mg/kg	1 (1)	24 hourly	Intra Muscular	-
1 mg/kg	1 (1)	24 hourly	Oral	-
Neonatal Dosage (3kg)
0.625 mg/kg	0.62 (0.625)	24 hourly	Intramuscular
0.625 mg/kg	0.62 (0.625)	24 hourly	Oral

High Risk Groups

Warning / Precautions

If patients have had a bad reaction (skin reaction, difficulty in swallowing or difficulty in breathing) to thiamine in the past, inform the doctor. Except in doses greater than recommended, thiamine is considered safe for use during pregnancy or lactation.

Storage Conditions

Interference in Pathology

Brands / Trade Names of Thiamine HCl (Vitamin B1)

Manufacturers of Thiamine HCl (Vitamin B1) in Pakistan

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