Topotecan (HCl)
Overview
Topotecan (HCl) is intravenous antineoplastic (anticancer) agent. Topotecan, similar to irinotecan, is a derivative of camptothecin (CPT), a cytotoxic plant alkaloid isolated from the Chinese tree Camptotheca acuminata. it, along with irinotecan, is the first of a new class of antineoplastics, the topoisomerse I inhibitors. Topotecan is a second-line treatment for ovarian carcinoma. It has also been investigated for treatment of non-small-cell lung carcinoma, and for chronic myelomonocytic leukemia (CMML). As a single agent, topotecan offers equal response rates to other antineoplastics for lung or ovarian carcinomas. its role in combination therapy has not yet been well defined. Topotecan was FDA approved May 29, 1996 for the treatment of metastatic ovarian carcinoma.
Categories
- 8 Antineoplastics, immunomodulators and drugs used in palliative care
Primary Characterstics
It is of Semi synthetic origin and belongs to Alkaloid. It belongs to Antineoplastic Agent, Plant Derivative pharmacological group.The Molecular Weight of Topotecan (HCl) is 457.90.
Indications
Back to top
Pharmacokinetics
Back to top
Contraindications
Back to top
Back to top
Side Effects
Back to top
Dosage
Topotecan (HCl)'s dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 1.5 mg/sq.meter | 3 (3) | 24 hourly | IV Inf | Initially for 5 Days |
| 1.5 mg/sq.meter | 3 (3) | 24 hourly | IV Inf | Maintenance for 21-Day Course |
Paedriatic Dosage (20kg)
|
| | | | Not recommended in this age group |
Neonatal Dosage (3kg)
|
| | | | Not recommended in this age group |
High Risk Groups
Back to top
Warning / Precautions
Back to top
Storage Conditions
Back to top
Interference in Pathology
Back to top
Brands / Trade Names of
Topotecan (HCl)
Back to top
Manufacturers of
Topotecan (HCl)
in Pakistan
Back to top
Previous Drug Generic - Next Drug Generic