Trimeprazine (Tartrate)

Overview

Trimeprazine (Tartrate) is a phenothiazine similar to chlorpromazine. Trimeprazine (Tartrate) is used as an antiemetic, sedative and antipruritic agent. Trimeprazine (Tartrate) is used in urticaria and for prolong relief of pruritic symptoms in a variety of allergic and non-allergic conditions.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

Oral absorption of Trimeprazine (Tartrate) is found to be 85% ±5. Plasma protien binding is > 90 %. Renal Excretion accounts for 70 % and plasma half life is 3.6 - 7 hr.

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Contraindications

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Drug Interactions

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Side Effects

The severe or irreversible adverse effects of Trimeprazine (Tartrate), which give rise to further complications include Hypoglycemia.

Trimeprazine (Tartrate) produces potentially life-threatening effects which include Respiratory depression, Hypotension, Malignant hyperpyrexia. which are responsible for the discontinuation of Trimeprazine (Tartrate) therapy.

The signs and symptoms that are produced after the acute overdosage of Trimeprazine (Tartrate) include Tachycardia, Respiratory failure, Hypoventilation, Extrapyramidal effects, Anticholinergic effects.

The symptomatic adverse reactions produced by Trimeprazine (Tartrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Dry mouth, Depression, Nasal congestion, Galactorrhea, Vivid dreams, Photosensitive dermatitis, Abdominal discomfort.

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Dosage

Trimeprazine (Tartrate)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

0.19 mg/kg0.19 (0.19)8 hourlyPO-

Paedriatic Dosage (20kg)

0.25 mg/kg0.25 (0.25)8 hourlyOral-

Neonatal Dosage (3kg)

0.25 mg/kg0.25 (0.25)8 hourlyOral

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Trimeprazine (Tartrate)

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Manufacturers of Trimeprazine (Tartrate) in Pakistan

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