Zolpidem (Tartrate)
Overview
Zolpidem (Tartrate) is a non-benzodiazepine sedative-hypnotic for the short-term treatment of insomnia. Although chemically unrelated to other hypnotics such as the benzodiazepines or barbiturates, zolpidem does share some pharmacological actions with these drugs. Unlike the benzodiazepines, zolpidem produces muscle relaxation and anticonvulsant effects only at doses much higher than the hypnotic dose. Zolpidem has a short half-life and no active metabolites. Therefore, a next-day "hangover" effect and CNS depression are less for zolpidem than the barbiturates. Treatment of insomnia with zolpidem should be restricted to a period of 7-10 days. Zolpidem received FDA approval in 1993.
Categories
- 24 Psychotherapeutic drugs
Primary Characterstics
Indications
Back to top
Pharmacokinetics
Back to top
Contraindications
Back to top
Drug Interactions
Zolpidem (Tartrate) is known to interact with other drugs, the details of drug interactions is as follows:
Severity N/A
Phenytoin (Na) Interaction of Phenytoin (Na) with Zolpidem (Tartrate)
Isoniazid Interaction of Isoniazid with Zolpidem (Tartrate)
Carbamazepine Interaction of Carbamazepine with Zolpidem (Tartrate)
Alcohol Interaction of Alcohol with Zolpidem (Tartrate)
Rifampicin Interaction of Rifampicin with Zolpidem (Tartrate)
Phenobarbitone Interaction of Phenobarbitone with Zolpidem (Tartrate)
Nelfinavir Interaction of Nelfinavir with Zolpidem (Tartrate)
Nevirapine Interaction of Nevirapine with Zolpidem (Tartrate)
Ritonavir Interaction of Ritonavir with Zolpidem (Tartrate)
VORICONAZOLE Interaction of VORICONAZOLE with Zolpidem (Tartrate)
Details: Voriconazole may increase the serum concentration of zolpidem by decreasing its metabolism.
Management: Consider alternate therapy or monitor for changes in the therapeutic and adverse effects
These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Back to top
Side Effects
The severe or irreversible adverse effects of Zolpidem (Tartrate), which give rise to further complications include Dementia.
The symptomatic adverse reactions produced by Zolpidem (Tartrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Confusion, GI upset, Depression, Tremor.
Back to top
Dosage
Zolpidem (Tartrate)'s dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 10 mg | 10 (10) | 24 hourly | PO | |
Paedriatic Dosage (20kg)
|
| | | | Not recommended in this age group |
Neonatal Dosage (3kg)
|
| | | | Not recommended in this age group |
High Risk Groups
Drug should not be given to patients suffering from Liver Malfunction.
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Back to top
Warning / Precautions
Back to top
Storage Conditions
Tab
Store Below 40°C. Protect from Sunlight and Heat.
Back to top
Interference in Pathology
No data regarding the pathological interferences produced by Zolpidem (Tartrate) is available.
Back to top
Brands / Trade Names of
Zolpidem (Tartrate)
Click on the desired strength of the dosage form to view its available brands.
Single Ingredient
Tabs: 10 mg, 12.5 mg, 6.25 mg,
Back to top
Manufacturers of
Zolpidem (Tartrate)
in Pakistan
Back to top
Previous Drug Generic - Next Drug Generic