Amoxicillin

Overview

Amoxicillin is oral semisynthetic aminopenicillin similar to ampicillin. Amoxicillin is more stable to gastric acids and more bioavailable than other penicillins. It inhibits the 3rd and final stage of bacterial cell wall synthesis by binding to specific penicillin-binding proteins PBPs that are located inside the bacterial cell wall and are responsible for several steps in the synthesis of the cell wall. Chemically Amoxicillin is D-(-)-a-amino-p-hydroxy-benzyl penicillin. Amoxicillin is a broad spectrum antibiotic and has bactericidal activity against many gram positive and gram negative bacteria. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Amoxicillin is important to take the drug for the full time period as prescribed. If you discontinue the drug it may result in ineffective treatment.

Categories

• 6 Anti-infective drugs
  • 6.2 Antibiotics, systemic
    • 6.2.1 Beta-lactam drugs
      • 6.2.1.1 Penicillins

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Valaciclovir (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.25 to 0.5 g	0.38 (0.375)	8 hourly	PO,IV,IM	Doses vary according to indication. In typhoid fever and Meningitis , 150 mg/Kg/day in adults and 100-150 mg/kg/day in children should be given. Doses greater than 500 mg is given in divided doses.
Paedriatic Dosage (20kg)
50 to 100 mg/kg	75 (75)	6 hourly	Intra Muscular
50 to 100 mg/kg	75 (75)	6 hourly	Intra Venous
20 to 40 mg/kg	30 (30)	8 hourly	Oral
Neonatal Dosage (3kg)
12.5 to 25 mg/kg	19 (18.75)	6 hourly	Intramuscular
12.5 to 25 mg/kg	19 (18.75)	6 hourly	Intravenous

High Risk Groups

Drug should not be given to Cardiac / Hypertensive Patients, and patients suffering from Kidney dysfunction.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Valaciclovir (HCl)

Manufacturers of Amoxicillin in Pakistan

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