Amrinone (Lactate)

Overview

Amrinone (Lactate) is a vasodilator with positive inotropic properties, belongs to phosphodisterase inhibitors. Amrinone (Lactate) is used for the short term management of heart failure unresponsive to other forms of therapy. The mechanism of action has not been fully determined , however it appears to involve an increase in cAMP concentration due to inhibition of phosphodisterase leading to an increased contractile force in cardiac muscle. Amrinone (Lactate) is given by intravenous route.

Categories

• 12 Cardiovascular drugs
  • 12.4 Drugs used in heart failure

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

The severe or irreversible adverse effects of Amrinone (Lactate), which give rise to further complications include Cardiac arrhythmias, Hepatosplenomegaly, Hypotension, Hepatosplenomegaly.

The signs and symptoms that are produced after the acute overdosage of Amrinone (Lactate) include Thrombocytopenia.

The symptomatic adverse reactions produced by Amrinone (Lactate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fever, Local pain, Hypersensitivity reactions, Chest pain, GI disturbance, Nail discoloration.

Dosage

Amrinone (Lactate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
5 to 10 mcg per kg of body weight per minute	7.5 (7.5)	As recommended.	IV	Ths is maintanance dose. the dose should be adjusted according to clinical response. Up to 10 mg (base) per kg of body weight per day, although some patients have been given doses up to 18 mg per kg per day for short durations.
750 mcg per kg of body weight.	750 (750)	As recommended.	IV	Ths is initial dose and is given undiluted slowly over 2-3 mnutes;may be repeated after 30 minutes if necessary.
Paedriatic Dosage (20kg)
No data regarding the Paedriatic dosage details of Amrinone (Lactate) is available.
Neonatal Dosage (3kg)
No data regarding the neonatal dosage details of Amrinone (Lactate) is available.

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Amrinone (Lactate)

Manufacturers of Amrinone (Lactate) in Pakistan

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