Benzhexol (HCl)

Overview

Chlorpromazine (HCl) is the hydrochloride salt of chlorpromazine which is a phenothiazine derivative. It is used as an antiemetic, antipsychotic and tranquilizer. Chlorpromazine (HCl) is administered by rectal suppositories.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

Chlorpromazine (HCl) is contraindicated in conditions like Epilepsy, Myasthenia gravis, Narrow-angle glaucoma, Parkinson's disease, Depressed level of conciousness.

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Drug Interactions

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Side Effects

The severe or irreversible adverse effects of Chlorpromazine (HCl), which give rise to further complications include Cholestatic jaundice, Cholestatic jaundice, Photosensitivity, Paralytic ileus, Impotence, Blood dyscrasias, Gynecomastia, Respiratory failure, bilirubinemia, icterus, blood dyscrasias.

Chlorpromazine (HCl) produces potentially life-threatening effects which include Seizures, Blood dyscrasias, Neuroleptic Malignant Syndrome, Temperature disorders, Ventricular arrhythmias, Neuroleptic malignant syndrome, Jaundice, Tradive dyskinesia. which are responsible for the discontinuation of Chlorpromazine (HCl) therapy.

The signs and symptoms that are produced after the acute overdosage of Chlorpromazine (HCl) include Hypotension, Tachycardia, Coma, Hypothermia, Tachypnea, Decreased diastolic BP, Somnolence.

The symptomatic adverse reactions produced by Chlorpromazine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Constipation, Insomnia, Skin rashes, Dry mouth, Blurred vision, Allergic reactions, Akathisia, Nasal stiffiness, Weight gain, Diaphoresis, Acute dystonia, Skin pigmentation, Faintness, Decrease in libido, Galactorrhea, HyperprolactinemiaX, Adverse behavioral reactions, Amenorrhea, Xerostomia, Ocular complicaions, Urinary retention, Dry mouth, Skin rashes, dizziness, faintness, Palpitations, anticholnergic efforts, worsening of glaucoma.

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Dosage

Benzhexol (HCl)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

1 to 2 mg daily1.5 (1.5)24 hourlyPOTrihexyphenidyl HCl in Idiopathic Parkinsonism:1mg is administered on first day and then increased by 2mg increments at intervals of three to five days, until a total of 6 to 10 mg is given daily. The total daily dose will depend upon what is found to be the optimal level. Many patients derive maximum benefit from this daily total of 6 to 10 mg, but some patients, chiefly those in the post-encephalitic group, may require a total daily dose of 12 to 15 mg.
5 to 15 mg daily10 (10)24 hourlyPOTrihexyphenidyl HCl in Drug-Induced Parkinsonism:It may be advisable to commence therapy with a single 1 mg dose. If the extrapyramidal manifestations are not controlled in a few hours, the subsequent doses may be progressively increased until satisfactory control is achieved.

Paedriatic Dosage (20kg)

0.16 mg/kg0.16 (0.16)24 hourlyOralNot recommended under 3 yrs. Dose for 5-12 Yrs of Children

Neonatal Dosage (3kg)

Not recommended under 3 yrs.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Benzhexol (HCl)

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Manufacturers of Benzhexol (HCl) in Pakistan

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