Calcipotriol

Overview

Calcipotriol is a synthetic analogue of vitamin D, a fat soluble sterol, sometimes considered to be hormone or hormone precursor. Calcipotriol is involved in promoting normal bone development in body by regulating calcium, phosphorus and minerals. Vitamin D is a secosteroid and sometimes popularly known as the 'sunshine vitamin' because formed in the skin from 7-dehydrocholesterol under the influence of ultraviolet irradiation. Calcipotriol is also found in certain food. Fish liver oils, especially code liver oil are good sources of vitamin D. Calipotriol effects cell division and differentiation. At the cellular level the action of calcipotriol is very similar preparation for psoriosis to that of the natural hormones calcitriol or 1, 25 dihydroxy Vit D where or its systemic effects on Ca.

Categories

• 13 Dermatological drugs (topical)
  • 13.9 Anti-psoriatics

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Calcipotriol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.005 %	0.005 (0.005)	12 hourly	Topical	No more than 100g ofcream or ointment of 60ml of scalp solution should be applied in 1 week if both are used than maximum 60gm of cream/ointment
Paedriatic Dosage (20kg)
				Not Recommended in this Age Group
Neonatal Dosage (3kg)
				Not recommended in this age group

High Risk Groups

Warning / Precautions

Calcipotriol should be used with caution in elderly. It should not be used in patients with disorder of calcium metabolism and with a history of hypersensitivity reactions. Ointment should not be used on the face since the ointment formulation may give rise to irritation of the facial skin. Careful hand washing after use is recommended. It is classified as pregnancy category C should be used only when the benefit of therapy outweighs the risk to fetus. It should be used with caution in generalized pustular or erythrodermic exfoliative psoriasis.Avoid use in face and excessive exposure to sun light and sunlamps.

Storage Conditions

Interference in Pathology

Brands / Trade Names of Calcipotriol

Manufacturers of Calcipotriol in Pakistan

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