Clonazepam

Overview

Primary Characterstics

It is of Synthetic origin and belongs to Benzodiazepines. It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Benzodiazepine pharmacological group.The Molecular Weight of Clonazepam is 315.70.

Its pKa is 1.5, 10.5.

Indications

Pharmacokinetics

Contraindications

Clonazepam is contraindicated in conditions like Respiratory depression, Acute pulmonary insufficiency, Hypersensitivity.

Drug Interactions

Clonazepam is known to interact with other drugs, the details of drug interactions is as follows:

Interaction of Carbamazepine with Clonazepam

Details: Carbamazepine often reduces plasma concentration of Clonazepam.

Valproic Acid

Interaction of Valproic Acid with Clonazepam

Details: Concurrent administration has been associated with the development of absence status epileptitis,however this complication appears to be rare.

VORICONAZOLE

Interaction of VORICONAZOLE with Clonazepam

Details: Voriconazole may increase the serum concentration of clonazepam by decreasing its metabolism.

Management: Monitor for clonazepam toxicity if voriconazole is initiated or dose increased.

Moderate

Iproniazid Phosphate

Interaction of Iproniazid Phosphate with Clonazepam

Details: Infrequent reports of CLONAZEPAM increasing the EXTRAPYRAMIDAL side effects of IPRONIAZID.

Iprindole

Interaction of Iprindole with Clonazepam

Details: Theoretical potential for CLONAZEPAM increasing the SEDATIVE effect of IPRINDOLE.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Dosage

Clonazepam's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.125 to 1 mg	0.56 (0.5625)	24 hourly	PO	Initial
1 to 4 mg	2.5 (2.5)	24 hourly	PO	Maintenance
Paedriatic Dosage (20kg)
25 ug/kg	25 (25)	24 hourly	Oral	Initially at night
50 to 150 ug/kg	100 (100)	12 hourly	Oral	Maintenance
Neonatal Dosage (3kg)
31.25 ug/kg	31 (31.25)	24 hourly	oral	load for once
62.5 ug/kg	62 (62.5)	12 hourly	oral	Maintenance, As required

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

It should be used with caution in patients with chronic pulmonary insufficiency, or impairment of hepatic or renal function and in debilitated patients. Perform periodic blood counts and liver function tests during long term therapy. Clonazepam should be used with caution in patients if increased salivation cause respiratory difficulty, because it may produce an increase in salivation. Give least amount of drug to patients in whom depression accompanies anxiety and suicidal tendencies may be present. It should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity because it may cause allergic reaction (including bronchial asthma).

Storage Conditions

Interference in Pathology

Liver Function Test (LFT)
Periodic blood count

Brands / Trade Names of Clonazepam

Click on the desired strength of the dosage form to view its available brands.

Single Ingredient

Drops: 0.25 %w/v,
Tabs: 1 mg, 2 mg, 0.5 mg,

Manufacturers of Clonazepam in Pakistan

English Geofman Gray's Jinnah Lowitt Polyfine Raazee Sami Saydon Schazoo Tagma Usawa Wilshire Z-Jans Zafa

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Clonazepam

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