Demeclocycline (HCl)

Overview

Demeclocycline is a tetracycline antibiotic. Tetracyclines are derivatives of polycyclic naphthacenecarboxamide. Tetracyclines are broad spectrum antibiotic. They are bacteriostatic and effective against many gram positive and gram negative bacterias. Demeclocycline was obtained by the demethylation of chlortetracycline. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular interval of time throughout the day and night as prescribed. Demeclocycline (HCl) is important to take the drug for the full time period as prescribed. If you discontinue the drug, it may result in ineffective treatment.

Categories

• 6 Anti-infective drugs
  • 6.2 Antibiotics, systemic
    • 6.2.2 Other anti-bacterial drugs
      • 6.2.2.3 Tetracyclines

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Contraindications

Drug Interactions

Side Effects

Dosage

Demeclocycline (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
600 to 900 mg	750 (750)	As recommended.	Atypical pneumonia.	Maintenance dose.
900 mg	900 (900)	24 hourly	PO	For atypical pneumonia
900 to 1200 mg	1000 (1050)	As recommended.	PO	Given as initial dose in Chronic hyponatraemia in divided dose.
Paedriatic Dosage (20kg)
				Not Recommended in this Age Group
Neonatal Dosage (3kg)
				Not Recommended in this Age Group

High Risk Groups

Warning / Precautions

Demeclocycline should be used with caution (if contain tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma). Take appropriate measures if secondary infection occurs. Perform periodic laboratory evaluation of organ system (e.g. liver or kidney) in case of long term therapy.

Storage Conditions

Interference in Pathology

Brands / Trade Names of Demeclocycline (HCl)

Manufacturers of Demeclocycline (HCl) in Pakistan

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