deferoxamine Overview Deferoxamine is iron chelator. Deferoxamine is used in the treatment of acute iron poisoning and in conditions in which excessive iron is stored in tissues. Categories 4 Antidotes and other substances used in poisonings4.2 Specific antidotes4.2.4 Iron poisoning and iron & aluminium overload Page headings Overview Primary Characterstics Indications Pharmacokinetics Contraindications Drug Interactions Side Effects Dosage High Risk Groups Warning / Precautions Storage Conditions Interference in Pathology Brands of Deferoxamine Manufacturers of Deferoxamine Primary Characterstics Indications Back to top Pharmacokinetics Back to top Contraindications Back to top Drug Interactions deferoxamine is known to interact with other drugs, the details of drug interactions is as follows:Severity N/AProchlorperazine Interaction of Prochlorperazine with deferoxamineFolic Acid Interaction of Folic Acid with deferoxamineEpoetin Interaction of Epoetin with deferoxamineMethotrimeprazine (Maleate) Interaction of Methotrimeprazine (Maleate) with deferoxaminePromazine (HCl) Interaction of Promazine (HCl) with deferoxamineSulpiride Interaction of Sulpiride with deferoxamineAmisulpride Interaction of Amisulpride with deferoxamine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. Back to top Side Effects Back to top Dosage Deferoxamine's dosage details are as follows: Dose Single Dose Frequency Route Instructions Adult Dosage 15 mg/kg/hr15 (15)As recommended.Cont. IV-infFor acute Iron poisoning Max. 80 mg/kg in 24 hrs0.5 to 1 g0.75 (0.75)As recommended.IMFor Chronic Iron over Load.This dose is given as initial dose and maintainence dose is determined by response.5 mg/kg/hr5 (5)As recommended.IV-infFor aluminium over load.500 mg500 (500)As recommended.SC inf or IV infFor Chronic Iron over Load.Usual effective dose is 20-60 mg/kg.Subcutaneous infusions are given 3-7 times a week (usually over 8-12 hours ) depending on the degree of iron load10 %10 (10)As recommended.topicalAs eye drops for the treatment of Ocular siderosis and corneal rust stains Paedriatic Dosage (20kg) 28.571 mg/kg29 (28.571)24 hourlyIntra MuscularInitial71.428 mg/kg71 (71.428)As recommended.OralMaintenance, As Required Neonatal Dosage (3kg) 28.571 mg/kg29 (28.571)24 hourlyIntra MuscularInitial71.428 mg/kg71 (71.428)As recommended.OralMaintenance, As Required High Risk Groups Back to top Warning / Precautions Back to top Storage Conditions Back to top Interference in Pathology Back to top Brands / Trade Names of Deferoxamine Back to top Manufacturers of deferoxamine in Pakistan Nextar Novartis Back to top Previous Drug Generic - Next Drug Generic
deferoxamine Overview Deferoxamine is iron chelator. Deferoxamine is used in the treatment of acute iron poisoning and in conditions in which excessive iron is stored in tissues. Categories 4 Antidotes and other substances used in poisonings4.2 Specific antidotes4.2.4 Iron poisoning and iron & aluminium overload Page headings Overview Primary Characterstics Indications Pharmacokinetics Contraindications Drug Interactions Side Effects Dosage High Risk Groups Warning / Precautions Storage Conditions Interference in Pathology Brands of Deferoxamine Manufacturers of Deferoxamine Primary Characterstics Indications Back to top Pharmacokinetics Back to top Contraindications Back to top Drug Interactions deferoxamine is known to interact with other drugs, the details of drug interactions is as follows:Severity N/AProchlorperazine Interaction of Prochlorperazine with deferoxamineFolic Acid Interaction of Folic Acid with deferoxamineEpoetin Interaction of Epoetin with deferoxamineMethotrimeprazine (Maleate) Interaction of Methotrimeprazine (Maleate) with deferoxaminePromazine (HCl) Interaction of Promazine (HCl) with deferoxamineSulpiride Interaction of Sulpiride with deferoxamineAmisulpride Interaction of Amisulpride with deferoxamine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required. Back to top Side Effects Back to top Dosage Deferoxamine's dosage details are as follows: Dose Single Dose Frequency Route Instructions Adult Dosage 15 mg/kg/hr15 (15)As recommended.Cont. IV-infFor acute Iron poisoning Max. 80 mg/kg in 24 hrs0.5 to 1 g0.75 (0.75)As recommended.IMFor Chronic Iron over Load.This dose is given as initial dose and maintainence dose is determined by response.5 mg/kg/hr5 (5)As recommended.IV-infFor aluminium over load.500 mg500 (500)As recommended.SC inf or IV infFor Chronic Iron over Load.Usual effective dose is 20-60 mg/kg.Subcutaneous infusions are given 3-7 times a week (usually over 8-12 hours ) depending on the degree of iron load10 %10 (10)As recommended.topicalAs eye drops for the treatment of Ocular siderosis and corneal rust stains Paedriatic Dosage (20kg) 28.571 mg/kg29 (28.571)24 hourlyIntra MuscularInitial71.428 mg/kg71 (71.428)As recommended.OralMaintenance, As Required Neonatal Dosage (3kg) 28.571 mg/kg29 (28.571)24 hourlyIntra MuscularInitial71.428 mg/kg71 (71.428)As recommended.OralMaintenance, As Required High Risk Groups Back to top Warning / Precautions Back to top Storage Conditions Back to top Interference in Pathology Back to top Brands / Trade Names of Deferoxamine Back to top Manufacturers of deferoxamine in Pakistan Nextar Novartis Back to top Previous Drug Generic - Next Drug Generic