deferoxamine
Overview
Deferoxamine is iron chelator. Deferoxamine is used in the treatment of acute iron poisoning and in conditions in which excessive iron is stored in tissues.
Categories
- 4 Antidotes and other substances used in poisonings
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Deferoxamine's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 15 mg/kg/hr | 15 (15) | As recommended. | Cont. IV-inf | For acute Iron poisoning Max. 80 mg/kg in 24 hrs |
| 0.5 to 1 g | 0.75 (0.75) | As recommended. | IM | For Chronic Iron over Load.This dose is given as initial dose and maintainence dose is determined by response. |
| 5 mg/kg/hr | 5 (5) | As recommended. | IV-inf | For aluminium over load. |
| 500 mg | 500 (500) | As recommended. | SC inf or IV inf | For Chronic Iron over Load.Usual effective dose is 20-60 mg/kg.Subcutaneous infusions are given 3-7 times a week (usually over 8-12 hours ) depending on the degree of iron load |
| 10 % | 10 (10) | As recommended. | topical | As eye drops for the treatment of Ocular siderosis and corneal rust stains |
Paedriatic Dosage (20kg)
|
| 28.571 mg/kg | 29 (28.571) | 24 hourly | Intra Muscular | Initial |
| 71.428 mg/kg | 71 (71.428) | As recommended. | Oral | Maintenance, As Required |
Neonatal Dosage (3kg)
|
| 28.571 mg/kg | 29 (28.571) | 24 hourly | Intra Muscular | Initial |
| 71.428 mg/kg | 71 (71.428) | As recommended. | Oral | Maintenance, As Required |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Deferoxamine
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