Severity N/A
Amitriptyline (HCl) Interaction of Amitriptyline (HCl) with Disulfiram
Carbamazepine Interaction of Carbamazepine with Disulfiram
Rifampicin Interaction of Rifampicin with Disulfiram
Phenazone Interaction of Phenazone with Disulfiram
Pethidine (HCl) Interaction of Pethidine (HCl) with Disulfiram
Morphine Interaction of Morphine with Disulfiram
Chlorpromazine (HCl) Interaction of Chlorpromazine (HCl) with Disulfiram
Methotrimeprazine (Maleate) Interaction of Methotrimeprazine (Maleate) with Disulfiram
Metronidazole Interaction of Metronidazole with Disulfiram
Prazepam Interaction of Prazepam with Disulfiram
Promazine (HCl) Interaction of Promazine (HCl) with Disulfiram
Sulpiride Interaction of Sulpiride with Disulfiram
Alprazolam Interaction of Alprazolam with Disulfiram
Aminophylline Interaction of Aminophylline with Disulfiram
Amisulpride Interaction of Amisulpride with Disulfiram
Sulbactam Interaction of Sulbactam with Disulfiram
Oxtriphylline (Choline Theophyllinate) Interaction of Oxtriphylline (Choline Theophyllinate) with Disulfiram
Fosphenytoin Interaction of Fosphenytoin with Disulfiram
Ritonavir Interaction of Ritonavir with Disulfiram
Chlorzoxazone Interaction of Chlorzoxazone with Disulfiram
Nafcillin Interaction of Nafcillin with Disulfiram
Details: Disulfiram may increase Nafcillin sodium levels.
Interaction of Esomeprazole with Disulfiram
Details: Coadministration results in toxicity
Interaction of Paraldehyde with Disulfiram
Details: Concurrent use is not recommended, but may be required in some cases.If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interaction of Sulfapyridine with Disulfiram
Details: Concurrent use with sulfonamides may result in an increased incidence of hepatotoxicity. Patients, especially those on prolonged administration or those with a history of liver disease.
Management: Should be carefully monitored.
Major
Alcohol Interaction of Alcohol with Disulfiram
Details: Disulfiram inhibit enzyme aldehyde dehydrogenase responsible for oxidation of acetaldehyde to acetylCoA thusduring cosumption of alcohol flushing,nausea,blurred vision,hypotension and tachycardia may occur.
Management: Alcohol should be avoided in patients receiving disulfiram.
Interaction of Iproniazid Phosphate with Disulfiram
Details: Infrequent reports of IPRONIAZID increasing the CNS TOXICITY of DISULFIRAM.
Management: May need to avoid combination.
Moderate
Isoniazid Interaction of Isoniazid with Disulfiram
Details: Coadministration causes blockade of dopamine metabolism and results in excess dopaminergic activity.
Management: Closely monitored the altered mental status.Dose of disulfiram must be adjusted.
Interaction of Phenytoin (Na) with Disulfiram
Details: Disulfiram may inhibit hepatic microsomal metabolism of phenytoin and decreases its elimination rate thus increasing serum level upto 73% to 500%.
Management: closely observed yhe serum level and toxicity of phenytoin.
Interaction of Metronidazole with Disulfiram
Details: Coadministration results in confusion and acute psychoses.
Management: Metronidazole should not be administered when using disulfiram.
Interaction of Podophyllum with Disulfiram
Details: The risk of peripheral neuropathy may be increased during concurrent use of two or more agents that are associated with this adverse effect. In some cases, the neuropathy may progress or become irreversible despite discontinuation of the medications.
Management: Caution is advised during concomitant use of agents with neurotoxic effects. Patients should be monitored closely for symptoms of neuropathy such as burning, tingling, pain, or numbness in the hands and feet. Since the development of peripheral neuropathy may be dose-related for many drugs, the recommended dosages should generally not be exceeded.
Interaction of Warfarin (Na) with Disulfiram
Details: Disulfiram may increase the serum concentration of Warfarin.
Onset: Delayed
Management: Monitor for increased therapeutic effects of Warfarin if Disulfiram is initiated/dose increased, or decreased effects if Disulfiram is discontinued/dose decreased.