Doxacurium
Overview
Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant. The neuromuscular block produced by doxacurium chloride may be antagonized by anticholinesterase agents. As with other nondepolarizing neuromuscular blocking agents, the more profound the neuromuscular block at reversal, the longer the time and the greater the dose of anticholinesterase required for recovery of neuromuscular function. Doxacurium chloride is approximately 2.5 to 3 times more potent than pancuronium and 10 to 12 times more potent than metocurine. Doxacurium chloride binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine.
Categories
- 1 Drugs used in anesthesia
Primary Characterstics
Indications
Back to top
Pharmacokinetics
Back to top
Back to top
Back to top
Side Effects
Back to top
Dosage
Doxacurium's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| No data regarding the Adult dosage details of Doxacurium is available. |
Paedriatic Dosage (20kg)
|
| No data regarding the Paedriatic dosage details of Doxacurium is available. |
Neonatal Dosage (3kg)
|
| No data regarding the neonatal dosage details of Doxacurium is available. |
High Risk Groups
Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Back to top
Warning / Precautions
Back to top
Storage Conditions
Back to top
Interference in Pathology
Back to top
Brands / Trade Names of
Doxacurium
Back to top
Previous Drug Generic - Next Drug Generic