Flurazepam (HCl)

Overview

Flurazepam (HCl) is a 1,4-benzodiazipine with long duartion of action. A substituent in the 7th position such as halogen or a nitro group is required for its sedative- hypnotic activity. Benzdiazipines are the most widely used anxiolytic drugs. The benzodiazipines are more effective and safer. They have largely replaced barbiturates and meprobamate in the treatment of anxiety.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

Oral absorption of Flurazepam (HCl) is found to be 100% . Plasma protien binding is 97%. Presystemic metabolism is noted to be 70% and metabolism is reported extensive by Liver. Renal Excretion accounts for >60% and plasma half life is 2.5 hr.

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Contraindications

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Drug Interactions

Flurazepam (HCl) is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Alcohol

Interaction of Alcohol with Flurazepam (HCl)

Cisapride

Interaction of Cisapride with Flurazepam (HCl)

Amprenavir

Interaction of Amprenavir with Flurazepam (HCl)

Details: Increased risk of prolonged sedation and respiratory depression when Amprenavir given with Flurazepam.
VORICONAZOLE

Interaction of VORICONAZOLE with Flurazepam (HCl)

Details: Voriconazole may increase the serum concentration of flurazepam by decreasing its metabolism.
Management: Monitor for flurazepam toxicity if voriconazole is initiated or dose increased.

Moderate

Lofepramine (HCl)

Interaction of Lofepramine (HCl) with Flurazepam (HCl)

Details: Theoretical potential for FLURAZEPAM increasing the SEDATIVE effect of LOFEPRAMINE.
Management: May need to avoid combination
Iprindole

Interaction of Iprindole with Flurazepam (HCl)

Details: Theoretical potential for FLURAZEPAM increasing the SEDATIVE effect of IPRINDOLE.
Management: May need to avoid combination.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

The severe or irreversible adverse effects of Flurazepam (HCl), which give rise to further complications include Aggression, Anxiety.

Flurazepam (HCl) produces potentially life-threatening effects which include Anaphylactoid reactions. which are responsible for the discontinuation of Flurazepam (HCl) therapy.

The signs and symptoms that are produced after the acute overdosage of Flurazepam (HCl) include Drowsiness, Ataxia, Dysarthria.

The symptomatic adverse reactions produced by Flurazepam (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Nausea, Constipation, Blurred vision, VertigoX, Hypotension, Light headedness, Slurred speech, Respiratory depression, Diminished libido, Feeling of hangover.

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Dosage

Flurazepam (HCl)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

0.214 to 0.428 mg/kg0.32 (0.321)24 hourlyPOAt Bed Time

Paedriatic Dosage (20kg)

Not Recommended in this Age Group

Neonatal Dosage (3kg)

Not recommended in this age group

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

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Warning / Precautions

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Storage Conditions

Caps

Store Below 40°C. Protect from Sunlight and Heat.

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Interference in Pathology

No data regarding the pathological interferences produced by Flurazepam (HCl) is available.

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Brands / Trade Names of Flurazepam (HCl)

Click on the desired strength of the dosage form to view its available brands.

Single Ingredient

Tabs: 15 mg,

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Manufacturers of Flurazepam (HCl) in Pakistan

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