Frusemide or Furosemide

Overview

Furosemide is an antihypertensive agent. Furosemide is a prototype drug of Loop Diuretics. Loop diuretics have much greater diuretic effects than thiazides. Furosemide is a sulfonamide derivative. It has a carboxyl group with a sulfamoyl moiety in the meta position. A halide or phenoxy substitution is present at carbon 4, and a substituted amino group is present at carbon 2 or 3. Furosemide is characterized by high efficacy and rapid onset of action. It increases the urination and decrease the amount of water retained in the body.

Categories

• 16 Diuretics
  • 16.2 Loop diuretics

Page headings

Primary Characterstics

Indications

Pharmacokinetics

Oral absorption of Frusemide or Furosemide is found to be 64.5% ±2.5. Volume of distribution is found to be 170-270 ml/kg and plasma protien binding is 98.6%. and metabolism is reported partly 35%. Renal Excretion accounts for major 65% and plasma half life is 45 to 60 min.

Contraindications

Drug Interactions

Side Effects

The severe or irreversible adverse effects of Frusemide or Furosemide, which give rise to further complications include Photosensitivity, Skin rashes, Ototoxicity, Nephrocalcinosis, Hyponatremia, Urinary retention, Dizziness, Blurred vision, Hyponatremia, Urinary retention.

Frusemide or Furosemide produces potentially life-threatening effects which include Hypokalemia, Cardiac arrhythmias, Hypomagnesemia, CHO intolerance, Hyperosmolar non-ketotic precoma, Hypokalemia, Ototoxicity, Hypochloremic alkalosis, deafness, Hypocalcemic tetany, Life threatening hyponatremia. which are responsible for the discontinuation of Frusemide or Furosemide therapy.

The signs and symptoms that are produced after the acute overdosage of Frusemide or Furosemide include Postural hypotension, Decreased GFR, Decreased intravascular volume, Sodium & fluid depletion, Serious potassium loss in urine.

The symptomatic adverse reactions produced by Frusemide or Furosemide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Nausea, Restlessness, Skin rashes, Dry mouth, Hypotension, Muscle cramps, Exfoliative dermatitis, Dry mouth, Skin rashes, thrist.

Dosage

Frusemide or Furosemide's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
20 to 80 mg	50 (50)	24 hourly	PO
40 mg	40 (40)	24 hourly	PO	Initially in Morning
Paedriatic Dosage (20kg)
0.5 to 1.5 mg/kg	1 (1)	24 hourly	Intra Muscular	-
0.5 to 1.5 mg/kg	1 (1)	24 hourly	Intra Venous	-
1 to 3 mg/kg	2 (2)	8 hourly	Oral
Neonatal Dosage (3kg)
0.5 to 1.5 mg/kg	1 (1)	24 hourly	Intra Muscular	-
0.5 to 1.5 mg/kg	1 (1)	24 hourly	Intra Venous	-
1 to 2 mg/kg	1.5 (1.5)	8 hourly	Oral	-

High Risk Groups

Warning / Precautions

Storage Conditions

Interference in Pathology

Brands / Trade Names of Frusemide or Furosemide

Manufacturers of Frusemide or Furosemide in Pakistan

Back to top