Glipizide

Overview

Categories

Primary Characterstics

Molecular Structure of Glipizide

Glipizide is also known as Glipizida, Glipizida.Glipizide is also known as Glipizida, Glipizida. It is of Synthetic origin and belongs to Sulphonyl Urea. It belongs to Potassium Channel (ATP sensitive) antagonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Sulfonylurea pharmacological group.The Molecular Weight of Glipizide is 445.00.

Its pKa is 5.9.

Indications

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Pharmacokinetics

Oral absorption of Glipizide is found to be 100% . Volume of distribution is found to be 0.14 l/kg and plasma protien binding is >98%. and metabolism is reported complete by Liver. Renal Excretion accounts for >80% and plasma half life is 2.4 hr.

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Contraindications

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Drug Interactions

Glipizide is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Alcohol

Interaction of Alcohol with Glipizide

Salicylic Acid

Interaction of Salicylic Acid with Glipizide

Trimethoprim

Interaction of Trimethoprim with Glipizide

Sulphamethizole

Interaction of Sulphamethizole with Glipizide

Details: Glipizide may be displaced from protein binding sites or their metabolism may be inhibited by some sulfonamides, resulting in increased or prolonged effects or toxicity.
Management: Dosage adjustments may be necessary during and after sulfonamide therapy

Moderate

Aspirin

Interaction of Aspirin with Glipizide

Details: Hypoglycemic effect of glipizide may be potentiated by aspirin by stimiulating insulin secretion.
Management: Closely monitor the development of hypoglycaemia.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Glipizide's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
2.5 to 5 mg3.8 (3.75)24 hourlyPO30 min before breakfast. Max dose 40 mg. Dose >15 mg given in 2 divided doses.

Paedriatic Dosage (20kg)
Not Recommended in this Age Group

Neonatal Dosage (3kg)
Not recommended in this age group

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Glipizide

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Manufacturers of Glipizide in Pakistan

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