Hydroflumethiazide

Overview

Hydroflumethiazide is a diuretic. It increases urination. Hydroflumethiazide is used in hypertention to lower the high blood pressure and also to treat fluid overload.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

Hydroflumethiazide is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Alcuronium (Cl)

Interaction of Alcuronium (Cl) with Hydroflumethiazide

Allopurinol

Interaction of Allopurinol with Hydroflumethiazide

Alcohol

Interaction of Alcohol with Hydroflumethiazide

Lithium

Interaction of Lithium with Hydroflumethiazide

Pancuronium (Br)

Interaction of Pancuronium (Br) with Hydroflumethiazide

Quinidine

Interaction of Quinidine with Hydroflumethiazide

Tubocurarine (Cl)

Interaction of Tubocurarine (Cl) with Hydroflumethiazide

Probenecid

Interaction of Probenecid with Hydroflumethiazide

Details: thiazide diuretics inhibits the uricosuric effects of probencid

Moderate

Digoxin

Interaction of Digoxin with Hydroflumethiazide

Details: Hydroflumethiazide may enhance the adverse/toxic effect of Digoxin. This by increasing the risk of hypokalemia.
Management: Monitor for increased toxic effects of Digoxin if Hydroflumethiazide is initiated or the dose is increased. The use of a potassium-sparing diuretic might be considered to minimize potassium loss. Likewise, potassium supplementation, along with careful monitoring of serum potassium and possibly Digoxin concentrations, might be helpful.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Hydroflumethiazide's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage
0.357 to 2.857 mg/kg1.6 (1.607)24 hourlyPOMaintenance, As Required
12.5 mg12 (12.5)As recommended.POInitially for Once. For Hypertension
25 to 50 mg38 (37.5)24 hourlyPOFor oedema.
25 to 100 mg62 (62.5)24 hourlyPOInitially given & reduce for maintanance.
50 to 100 mg75 (75)24 hourlyPOOn Alternate days.

Paedriatic Dosage (20kg)
1 mg/kg1 (1)24 hourlyOral-

Neonatal Dosage (3kg)
1 mg/kg1 (1)24 hourlyOral-

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Hydroflumethiazide

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Manufacturers of Hydroflumethiazide in Pakistan

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