Side Effects
The severe or irreversible adverse effects of Lignocaine, which give rise to further complications include Allergy, Bronchospasm, Tissue necrosis, Sinus bradycardia, Blurred vision, Hypotension, Coma, Angina, Respiratory depression, Tremors, Neonatal depression, Seizures, Hypertension, Malignant hyperthermia, Cardiovascular depression.
Lignocaine produces potentially life-threatening effects which include Respiratory depression, Bradycardia, Convulsions, Hypersensitivity, CNS toxicity, Cardiac Arrest, Tonic & clonic convulsion, Medullary depression. which are responsible for the discontinuation of Lignocaine therapy.
The signs and symptoms that are produced after the acute overdosage of Lignocaine include Bradycardia, Hypotension, Apnea, Death, Seizures, Respiratory arrest, Decrease cardiac output, Cardiovascular collapse.
The symptomatic adverse reactions produced by Lignocaine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Nausea, Vomiting, Anxiety, Restlessness, Palpitation, Nervousness, Tinnitus, Abdominal pain, Confusion, Tremor, Nystagmus, Abdominal discomfort, Twitching, nervousness.
Warning / Precautions
Lignocaine should be used with caution in patients receiving anti-coagulant therapy, with genetic predisposition of malignant hyperthermia, hypovolemia, shock and all types of heart block, congestive heart failure, bradycardia, respiratory depression or impaired liver or renal function. The injection of lignocaine should not be administered in areas of inflammation or infection. It should be avoided if plasma cholinesterase concentration is low.