Ephedrine

Overview

Sodium Valproate is anticonvulsant drug. It acts by potentiating GABA , an inhibitory neurotransmitter. Sodium Valproate is a drug of choice in all forms of epilepsy. Sodium Valproate is also used as the free acid i.e valproic acid, that was found to have an antiepileptic properties when used as a solvent in the search for other antiepileptic drug and Sodium Valproate is licensed for the acute manic attacks associated with bipolar disorders. The amides and esters of valproic acid are also active antileptic agents.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

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Side Effects

The severe or irreversible adverse effects of Sodium Valproate, which give rise to further complications include Thrombocytopenia.

Sodium Valproate produces potentially life-threatening effects which include Pancreatitis, Liver damage, Extrapyrimidal symptoms, Hyperammonemia. which are responsible for the discontinuation of Sodium Valproate therapy.

The signs and symptoms that are produced after the acute overdosage of Sodium Valproate include Deepening coma, Death.

The symptomatic adverse reactions produced by Sodium Valproate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weight gain, Tremor, Hair loss, GI disorders, Hematological disorder, Leucopenia, bone marrow depression, nocturnal enuresis, curly hair development.

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Dosage

Ephedrine's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

25 to 50 mg38 (37.5)As recommended.IM,SC
25 to 50 mg38 (37.5)As recommended.IM,SC,Slow IV
5 to 25 mg15 (15)As recommended.IVRepeated 5 to 10 minutes
0.5 to 1 %0.75 (0.75)As recommended.Nasal dropsfor the treatment of nasal congestion.
25 to 50 mg38 (37.5)4 hourlyPO

Paedriatic Dosage (20kg)

0.5 to 1 %0.75 (0.75)As recommended.NasalAs Required
1.5 mg/kg1.5 (1.5)8 hourlyOral-

Neonatal Dosage (3kg)

0.5 to 1 %0.75 (0.75)As recommended.NasalAs required
0.93 mg/kg0.93 (0.93)8 hourlyOral

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Ephedrine

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