Cisplatin
Overview
Cisplatin is an antineoplatsic drug. Cisplatin is inorganic metal complex with a planar configuration discovered by Rosenderg and his cholleagues. Only the cis isomer of Cisplatin is active. Cisplatin is effective in the treatment of different cancers to slow or stop the growth of abnormal or cancerous cells. Cisplatin is used in the treatment of metastatic testicular and ovarian tumours. Cisplatin is used in combination with different anticancerous drugs to obtain best therapeutic effects and to minimize side effects or toxicities.
Categories
- 8 Antineoplastics, immunomodulators and drugs used in palliative care
Primary Characterstics
Indications
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Pharmacokinetics
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Contraindications
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Side Effects
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Dosage
Cisplatin's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 50 to 70 mg/sq.meter | 60 (60) | As recommended. | IV | advanced bladder cancer once every 3 to 4 weeks. |
| 75 to 100 mg/sq.meter | 88 (87.5) | As recommended. | IV | Once every 4 weeks metastatic ovarian tumors. |
| 15 to 20 mg/ sq.meter/day | 18 (17.5) | As recommended. | IV Inf | For 5 days every month, As Required. Metastatic testicular tumors. |
Paedriatic Dosage (20kg)
|
| 32 to 17.5 mg/sq.meter | 25 (24.75) | 24 hourly | | |
| 15 to 20 mg/sq.meter | 18 (17.5) | 24 hourly | Intra Venous | For 5 Days, every 3-4 Weeks |
Neonatal Dosage (3kg)
|
| No data regarding the neonatal dosage details of Cisplatin is available. |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Cisplatin
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