Piretanide
Overview
Piretanide is a loop diuretic with actions, uses and adverse effects similar to those of frusemide. Piretanide is used in the management of mild to moderate hypertension associated with edema.
Primary Characterstics
Indications
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Pharmacokinetics
Oral absorption of Piretanide is found to be 86% ±6. Volume of distribution is found to be 12 - 17 litre and plasma protien binding is 94 %. Renal Excretion accounts for 45 % unchanged and plasma half life is 1 - 1.5 hr.
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Contraindications
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Drug Interactions
Piretanide is known to interact with other drugs, the details of drug interactions is as follows:
Moderate
Perindopril Interaction of Perindopril with Piretanide
Details: Infrequent reports of PIRETANIDE increasing the HYPOTENSIVE effect of Perindopril Erbumine .
These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
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Side Effects
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Dosage
Piretanide's dosage details are as follows:
| Dose
|
Single Dose
|
Frequency
|
Route
|
Instructions
|
Adult Dosage
|
| 6 to 24 mg/day | 15 (15) | As recommended. | PO | |
Paedriatic Dosage (20kg)
|
| No data regarding the Paedriatic dosage details of Piretanide is available. |
Neonatal Dosage (3kg)
|
| No data regarding the neonatal dosage details of Piretanide is available. |
High Risk Groups
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Warning / Precautions
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Storage Conditions
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Interference in Pathology
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Brands / Trade Names of
Piretanide
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