Pramiverine (HCl)

Overview

Cephradine is a first generation, semisynthetic analogue of natural cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cephradine is effective against gram positive and gram negative bacterias. Administered orally or by intramuscularly or by intravenous injection. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cephradine is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

Categories

Primary Characterstics

Indications

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Pharmacokinetics

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Contraindications

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Drug Interactions

Cephradine is known to interact with other drugs, the details of drug interactions is as follows:

Severity N/A

Ethacrynic Acid

Interaction of Ethacrynic Acid with Cephradine

Probenecid

Interaction of Probenecid with Cephradine

Netilmicin (Sulphate)

Interaction of Netilmicin (Sulphate) with Cephradine

Gentamicin

Interaction of Gentamicin with Cephradine

Tobramycin

Interaction of Tobramycin with Cephradine

Frusemide or Furosemide

Interaction of Frusemide or Furosemide with Cephradine

Details: Concomitant administeration leads to nephrotoxicity
Pivmecillinam (HCl)

Interaction of Pivmecillinam (HCl) with Cephradine

Details: Simultaneous administration of other Cephradine with Pivmecillinam (HCl) Tablets may produce a synergistic effect.
Protamine (Sulphate)

Interaction of Protamine (Sulphate) with Cephradine

Details: Protamine sulfate has been shown to be incompatible with Cephradine.

These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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Side Effects

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Dosage

Pramiverine (HCl)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

2.5 to 5 mg3.8 (3.75)As recommended.IM,Slow IVAs Required
2 mg2 (2)8 hourlyPO

Paedriatic Dosage (20kg)

No data regarding the Paedriatic dosage details of Pramiverine (HCl) is available.

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Pramiverine (HCl) is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Pramiverine (HCl)

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Manufacturers of Pramiverine (HCl) in Pakistan

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