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Manufacturer(s) of Pravastatin (Na) in Pakistan.

EverestFerrozaGSK
HiltonLowittMedicaids
Siza

Pravastatin (Na)

Overview

Pravastatin (Na) is a lipid-lowering agent, belongs to the group of drugs known as HMG-CoA reductase inhibitors which includes fluvastatin, lovastatin and simvastatin. More hydrophilic than the other members of this group unlike the others, pravastatin does not require hydrolysis for activation.Pravastatin (Na) is used for the treatment of primary hypercholesterolemia, and for primary prophylaxis of a myocardial infarction in patients with hypercholesterolemia who are at risk of a myocardial infarction. It was approved by the FDA in October 1991. It exerts it slipid lowering effects by inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase, an enzyme necessary for the intracellular synthesis of cholesterol. As a consequence of inhibiting HMG-CoA reductase, intracellular synthesis of cholesterol is impaired. This, in turn, increases the clearance of circulating LDL. In addition, pravastatin inhibits hepatic synthesis of VLDL, the precursor for LDL. The result is a reduction of circulating total cholesterol and LDL cholesterol.

Category:

Primary Characterstics

Molecular Structure of Pravastatin (Na)
Pravastatin (Na) also known as Eptastatin Na. . It is of Semi Synthetic origin and belongs to Naphalene. It belongs to HMGCoA reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent pharmacological group.The Molecular Weight of Pravastatin (Na) is 466.50.

Pharmacokinetics

Oral absorption of Pravastatin (Na) is found to be 34% . Volume of distribution is found to be 0.5 - 1 l/kg and plasma protien binding is 50 %. and metabolism is reported Hepatic. Renal Excretion accounts for 20 % and plasma half life is 1.5 - 2 hr.

Indications

Contraindications

Pravastatin (Na) is contraindicated in conditions like Hepatic disease.

Drug Interactions

No data regarding the interactions of Pravastatin (Na) was found.

Interference in Pathology

No data regarding the pathological interferences produced by Pravastatin (Na) is available.

Side Effects

The severe or irreversible adverse effects of Pravastatin (Na), which give rise to further complications include Cataract.

The symptomatic adverse reactions produced by Pravastatin (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Myositic syndrome, Elevation of CPK.

Available Brands

Click on the appropriate strength of the dosage form to view its available brands.

Single Ingredient

Tabs: 10 mg, 20 mg, 40 mg,

Dosage

Pravastatin (Na)'s dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

10 to 40 mg25 (25)24 hourlyPOAt night.

Paedriatic Dosage ( 20 Kg. )

Not recommended in this age group

Neonatal Dosage ( 3 Kg. )

Not recommended in this age group

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Warning / Precautions

Pravastatin should be used with caution in patients with any liver, kidney or heart disease, history of alcoholism, hypothyroidism or any allergy, especially drug allergies. Limit alcohol intake this may aggravate drug side effects. This drug should not be used during pregnancy or lactation.

Storage Conditions

Tab

Store Below 40°C. Protect from Moisture and Heat.

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