Mesna

Overview

Categories

Primary Characterstics

Indications

Mesna is primarily indicated in conditions like Cyclophosphamide induced hemorrhagic cystitis, Ifosfamide induced hemorrhagic cystitis, Prostate cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Cancer.

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Pharmacokinetics

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Contraindications

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Drug Interactions

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Side Effects

The signs and symptoms that are produced after the acute overdosage of Mesna include Diarrhea, Convulsions, Headache, Tremor.

The symptomatic adverse reactions produced by Mesna are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Diarrhea, Tachycardia, Abdominal pain, Hypotension, Cough, Bronchospasm, Limb pain, Joint pain, Exhaustion, Yellowing of teeth.

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Dosage

Mesna's dosage details are as follows:
Dose Single Dose Frequency Route Instructions

Adult Dosage

240 mg/m2240 (240)As recommended.IV Inf100-112% by weight of Ifosamide, As Required
1.625 to 1.82 g/sq.metre1.7 (1.7225)6 hourlyPO100-112% by weight of ifosamide

Paedriatic Dosage (20kg)

240 to 360 mg/sq.meter300 (300)8 hourlyIntra Venous20%w/w of Ifosfamide Dose

Neonatal Dosage (3kg)

No data regarding the neonatal dosage details of Mesna is available.

High Risk Groups

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Warning / Precautions

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Storage Conditions

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Interference in Pathology

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Brands / Trade Names of Mesna

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Manufacturers of Mesna in Pakistan

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